Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid-Reference-Cited by-同舟云学术

Eudragit®-based microcapsules of probucol with a gut-bacterial processed secondary bile acid

Published:2018-11 Issue:11 Volume:9 Page:811-821
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Mooranian Armin¹,Zamani Nassim¹,Mikov Momir²,Goločorbin-Kon Svetlana³,Stojanovic Goran⁴,Arfuso Frank⁵,Al-Salami Hani¹

Affiliation:

1. Biotechnology & Drug Development Research Laboratory, School of Pharmacy & Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia

2. Department of Pharmacology, Toxicology & Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia

3. Department of Pharmacy, University of Novi Sad, Novi Sad, Serbia

4. The Group for Nano and Flexible Electronics, Faculty of Technical Sciences, University of Novi Sad, Novi Sad, Serbia

5. Stem Cell & Cancer Biology Laboratory, School of Pharmacy & Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia

Abstract

Aim: Deoxycholic acid (DCA) has improved gliclazide oral absorption, while Eudragit® (ED) polymers have improved formulation stability of antidiabetic drugs. The aim of the study is to test if DCA and ED encapsulation will optimize the release and stability of the potential antidiabetic drug probucol (PB). Materials & methods: The PB formulations were prepared using ED polymers and DCA, and formulations were analyzed for their rheological and biological properties. Results: Rheological properties and size distribution were similar among all groups. β-cell survival and biological activities were best with NM30D microcapsules. The inflammatory profile and oxidative stress effects of microcapsules remained similar among all groups. Conclusion: ED NM30D and DCA incorporation can exert positive and stabilizing effects on PB oral microcapsules.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

http://www.future-science.com/doi/pdf/10.4155/tde-2018-0036

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