Skin toxicity of topically applied nanoparticles

Author:

Hashempour Sara1,Ghanbarzadeh Saeed2,Maibach Howard I3,Ghorbani Marjan4,Hamishehkar Hamed5

Affiliation:

1. Dermatology & Dermopharmacy Research Team, Student Research Committee & Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

2. Department of Pharmaceutics, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

3. Department of Dermatology, University of California, San Francisco, CA, USA

4. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

5. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Nowadays, nanoproducts have found numerous applications, allowing them to enter the human body in different ways. Skin is a major body organ that acts as the first-line barrier between the internal organs and external environment. Although the inhalation and ingestion of nanoparticles is more dangerous compared with skin exposure, there are noteworthy information gaps in skin exposure to nanoparticles that need much attention. Despite the few reviews in the literature on the cytotoxic effects of nanoparticles, no research has reviewed the clinical side effects of nanoparticles following topical admonition, including skin inflammation, skin cancer and genetic toxicity.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

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