Prevention of thrombotic disorders by antithrombotic diet and exercise: evidence by using global thrombosis tests

Author:

Yamamoto Junichiro1,Ijiri Yoshinobu2,Ikarugi Hideo3,Otsui Kazunori4,Inoue Nobutaka5,Sakariassen Kjell S6

Affiliation:

1. Kobe Gakuin University, Kobe 651–2180, Japan

2. Faculty of Health & Nutrition, Osaka Shoin Women's University, Osaka 577–8550, Japan

3. School of Economics, University of Hyogo, Kobe 651–2197, Japan

4. Clinical Department of General Internal Medicine, Kobe University Hospital, Kobe 650–0017, Japan

5. Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe 651–0053, Japan

6. KellSa s.a.s. Str. Campo e Zampo 12, I-13900 Biella, BI, Italy

Abstract

Prevention of thrombotic disorders has priority over treatment. There are only two pathologically relevant tests which are suitable for measuring the overall thrombotic status both in experimental conditions and in humans. The Global Thrombosis Test (GTT) and the Global Parallel-Plate Thrombosis Test can detect the pathologically relevant global thrombotic status. These tests have been successfully used for monitoring the effect of antithrombotic drugs and for developing novel antithrombotic agents. By using GTT, varieties of fruits, vegetables, and regular physical exercise have been tested for the effect on global thrombotic status. This review discusses the published evidence for the benefit of diet of selected fruit and vegetable varieties and doing regular physical exercise on improving thrombotic status. Future clinical trials monitored by GTT or Global Parallel-Plate Thrombosis Test could decide on the effectiveness of an experimentally proven antithrombotic diet with regular physical exercise in the prevention of thrombotic diseases.

Publisher

Future Science Ltd

Subject

Biotechnology

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