Omega-3 fatty acids in atherosclerosis and coronary artery disease

Author:

Bäck Magnus12

Affiliation:

1. Divison of Valvular & Coronary Disease, Department of Medicine, Karolinska Institutet, Karolinska University Hospital & Center for Molecular Medicine, Stockholm, Sweden

2. Nancy University Hospital, INSERM U1116 & University of Lorraine, Nancy, France

Abstract

Omega-3 polyunsaturated fatty acids have emerged as possible protective factors associated with a decreased risk for myocardial infarction in populations with a high marine food intake, which may relate to effects on lipid metabolism, thrombosis and inflammation. Omega-3 fatty acids decrease triglyceride levels and also compete as substrates for enzymes involved in the biosynthesis of lipid mediators. The balance between omega-3-derived specialized proresolving mediators and pro-inflammatory lipid mediators from arachidonic acid metabolism can be measured as the resolvin-to-leukotriene ratio, which has been shown to predict subclinical atherosclerosis. The results of experimental, observational and randomized studies of omega-3 fatty acids are somewhat variable and should be interpreted in view of the models used and the populations studied.

Publisher

Future Science Ltd

Subject

Biotechnology

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