Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer-Reference-Cited by-同舟云学术

Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer

Published:2018-12-01 Issue:10 Volume:4 Page:FSO345
ISSN:2056-5623
Container-title:Future Science OA
language:en
Short-container-title:Future Science OA

Author:

Maksymiuk Andrew W¹²,Sitar Daniel S²³,Ahmed Rashid⁴,Cheng Brian⁴,Bach Horacio⁵,Bagchi Rushita Adhikari⁶,Aroutiounova Nina⁶,Tappia Paramjit S⁷,Ramjiawan Bram³⁷

Affiliation:

1. Cancer Care Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada

2. Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3A 1R9, Canada

3. Department of Pharmacology & Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0T6, Canada

4. BioMark Diagnostics Inc., Richmond, British Columbia, V6X 2W8, Canada

5. Division of Infectious Diseases, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, V5Z 3J5, Canada

6. Department of Physiology & Pathophysiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada

7. Asper Clinical Research Institute & Office of Clinical Research, St. Boniface Hospital, Winnipeg, Manitoba, R2H 2A6, Canada

Abstract

Aim: SSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted. Results: High levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed. Conclusion: Increases in SSAT-1 contents in tumor tissue could be of value in targeting cancers with high SSAT-1 expression for confirmation/quantification. The high levels of acetylated amantadine could be used as a simple and useful screening test for the presence of cancer.

Publisher

Future Science Ltd

Subject

Biotechnology

Link

https://www.future-science.com/doi/pdf/10.4155/fsoa-2018-0077

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