Leveraging therapeutic potential of multi-targeted siRNA inhibitors-Reference-Cited by-同舟云学术

Leveraging therapeutic potential of multi-targeted siRNA inhibitors

Published:2009-12 Issue:9 Volume:1 Page:1671-1681
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Ge Qing¹,Xu John J¹,Evans David M¹,Mixson A James²,Yang Harry Y¹,Lu Patrick Y¹

Affiliation:

1. Sirnaomics, Inc., 401 Professional Drive, Suite 130, Gaithersburg, MD 20879, USA.

2. Department of Pathology, University of Maryland Baltimore, MSTF Building, 10 South Pine Street, Baltimore, MD 21201, USA

Abstract

While the discovery of RNA interference (RNAi) has been considered one of the most significant breakthroughs in biomedicine, its prospects for novel therapeutic applications are even more exciting. The high specificity, exquisite selectivity and chemical homogeneity of small interfering RNAs (siRNA; intermediates in RNAi activity), provide unique advantages for these moieties as multi-targeted inhibitory drugs. Many such applications have demonstrated significant benefit compared with single gene-targeted siRNA inhibitors. In this article, we will review the current status of using a multi-targeted siRNA cocktail for novel therapeutic development in the treatment of cancer and viral infections. We will also propose the characteristics of various types of siRNA cocktails and their design, while recognizing the potential future impact of and challenges facing this unique therapeutic modality.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.09.131

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