Biomarkers of doping: uses, discovery and validation

Author:

Aikin Reid1,Baume Norbert1,Equey Tristan1,Rabin Olivier1

Affiliation:

1. World Anti-Doping Agency, 800 Rue du Square-Victoria Suite 1700, Montreal, QC H4Z 1B7, Canada

Abstract

A biomarker of doping indicates the biological response to the use of a prohibited substance or method. Uncovering novel biomarkers of doping is a key objective in order to improve antidoping outcomes such as the detection of doping and changing athlete behavior toward doping practices. While the antidoping field has been successful in validating novel metabolites of prohibited substances, there has been less success in developing new biomarkers of doping. Employing the most suitable study designs and analytical approaches is critical to successfully uncovering novel biomarkers of doping with a high potential for translation into routine analysis. Here we argue that the antidoping field is well positioned for biomarker discovery and outline considerations for the development of novel biomarkers of doping.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Reference35 articles.

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4. World Anti-Doping Agency. WADA Independent Commission Report 1, Chapter 11 (2015). http://www.wada-ama.org/sites/default/files/resources/files/wada_independent_commission_report_1_en.pdf

5. Cycling Independent Reform Commission. Report to the President of the Union Cycliste Nationale. (2015). http://www.uci.org/docs/default-source/imported-library/circreport2015_neutral.pdf?sfvrsn=7a9764d3_14

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