Theoretical study of bone cancer therapy by plasmonic nanoparticles

Abstract

Background: Progress made by the scientific community in the understanding of cell receptors and metabolic pathways has led to discovery of chemical and protein agents which act as delivery vectors to specific tissues. Conjugating these agents to noble-metal nanoparticles allows for subsequent accumulation on or within targeted cells. Utilizing the unique light absorption properties of these nanoparticles then allows for photothermal heating of the particles and surrounding tissue. Discussion: The heat equations are solved for the case of gold nanoparticles in biological hard tissues, such as bone, for applications to two future cancer therapies: nanophotothermolysis and nanophotohyperthermia. Conclusions: A survey of recent research in bone-targeting bioconjugates and simulations of nanoparticle thermal fields shows promise for these therapies in the near future.