Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010-Reference-Cited by-同舟云学术

Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010

Published:2021-05 Issue:3 Volume:10 Page:111-163
ISSN:2046-8954
Container-title:Pharmaceutical Patent Analyst
language:en
Short-container-title:Pharmaceutical Patent Analyst

Author:

Brennecke Benjamin¹,Gazzi Thais¹,Atz Kenneth²^ORCID,Fingerle Jürgen²,Kuner Pascal²^ORCID,Schindler Torsten²,Weck Guy de²,Nazaré Marc¹^ORCID,Grether Uwe²^ORCID

Affiliation:

1. Medicinal Chemistry, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) Berlin, Berlin, 13125, Germany

2. Roche Pharma Research & Early Development, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd, Basel, 4070, Switzerland

Abstract

The G-protein-coupled cannabinoid receptor type 2 (CB2R) is a key element of the endocannabinoid (EC) system. EC/CB2R signaling has significant therapeutic potential in major pathologies affecting humans such as allergies, neurodegenerative disorders, inflammation or ocular diseases. CB2R agonism exerts anti-inflammatory and tissue protective effects in preclinical animal models of cardiovascular, gastrointestinal, liver, kidney, lung and neurodegenerative disorders. Existing ligands can be subdivided into endocannabinoids, cannabinoid-like and synthetic CB2R ligands that possess various degrees of potency on and selectivity against the cannabinoid receptor type 1. This review is an account of granted CB2R ligand patents from 2010 up to the present, which were surveyed using Derwent Innovation®.

Publisher

Future Science Ltd

Subject

General Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/ppa-2021-0002

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