Dithiolethiones: a privileged pharmacophore for anticancer therapy and chemoprevention

Author:

Ansari Mohd Imran1,Khan Mohd M2,Saquib Mohammad3,Khatoon Shahnaaz4,Hussain Mohd Kamil5

Affiliation:

1. Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 North Pine St., Baltimore, MD 21201, USA

2. University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA

3. Department of Chemistry, S. S. Khanna Girls Degree College, Allahabad, Uttar Pradesh 211003, India

4. Department of Botany, D.N. College, Meerut, Uttar Pradesh 250002, India

5. Department of Chemistry, Govt. Raza PG College, Rampur, Uttar Pradesh 244901, India

Abstract

Dithiolethiones are five-membered sulfur-containing cyclic scaffolds that exhibit antioxidative, anti-inflammatory, antithrombic and chemotherapeutic activities. Dithiolethiones display the chemopreventive and cytoprotective effects by activating the antioxidant response element and mounting the transcription of cytoprotective phase II enzymatic machinery. In addition, several classes of dithiolethiones efficiently modulate the activities of proteins that play crucial roles in normal and cancer cells, including glutathione S-transferase, cyclooxygenases and master regulator NF-κB. The present paper summarizes synthetic aspects, pharmacological potentials and biological attributes of dithiolethiones and its derivatives. Additionally, this review concludes with a discussion on how the current state-of-the-art technologies may help in defining a structure–activity relationship of dithiolethiones, thereby facilitating the design and synthesis of potent drug candidates.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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