A fruitful decade for fungal polyketides from 2007 to 2016: antimicrobial activity, chemotaxonomy and chemodiversity

Author:

Hussain Hidayat1,Al-Sadi Abdullah M2,Schulz Barbara3,Steinert Michael3,Khan Ajmal14,Green Ivan R5,Ahmed Ishtiaq6

Affiliation:

1. UoN Chair of Oman's Medicinal Plants & Marine Natural Products, University of Nizwa, PO Box 33, Birkat Al Mauz, Nizwa 616, Sultanate of Oman

2. Department of Crop Sciences, College of Agricultural & Marine Sciences, Sultan Qaboos University, PO Box 34, Al Khod 123, Oman

3. Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 31806 Braunschweig, Germany

4. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan

5. Department of Chemistry & Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch, Western Cape, 7600, South Africa

6. Karlsruhe Institute of Technology (KIT), DFG Centre for Functional Nanostructures, Wolfgang Gaede Strasse 1, 76131 Karlsruhe, Germany

Abstract

The last three decades have shown that the fungi can be ‘biofactories’ of novel, bioactive secondary metabolites that produce numerous natural products with novel skeletons and biological activities. Particularly in the last 10 years, large numbers of antimicrobial fungal secondary metabolites have been discovered. This review provides an overview of key, defining developments of the last 10 years regarding the discovery of antimicrobial activity, chemotaxonomy and chemodiversity of fungal polyketides.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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