Affiliation:
1. Newcastle Cancer Centre, School of Natural & Environmental Sciences, Bedson Building, Newcastle University, Newcastle, NE1 7RU, UK
Abstract
Inhibition of CDKs is an attractive approach to cancer therapy due to their vital role in cell growth and transcription. Pan-CDK inhibitors have shown some clinical benefit, and trials are ongoing. Selective CDK4 and CDK6 inhibitors have been licensed for the treatment of hormone responsive, RB-positive breast cancer in combination with antihormonal agents. Selective inhibitors of CDKs 5, 7, 8, 9 and 12 have been identified across a range of chemotypes.
Subject
Drug Discovery,Pharmacology,Molecular Medicine
Cited by
35 articles.
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