RGD-mediated delivery of small-molecule drugs-Reference-Cited by-同舟云学术

RGD-mediated delivery of small-molecule drugs

Published:2017-04 Issue:6 Volume:9 Page:579-604
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Katsamakas Sotirios¹,Chatzisideri Theodora²,Thysiadis Savvas²,Sarli Vasiliki²

Affiliation:

1. Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece

2. Department of Chemistry, Aristotle University of Thessaloniki, University Campus, 54124, Thessaloniki, Greece

Abstract

Conjugates of cytotoxic agents with RGD peptides (Arg-Gly-Asp) addressed to ανβ3, α5β1 and ανβ6 integrin receptors overexpressed by cancer cells, have recently gained attention as potential selective anticancer chemotherapeutics. In this review, the design and the development of RGD conjugates coupled to different small molecules including known cytotoxic drugs and natural products will be discussed.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc-2017-0008

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