Multiple target-centric strategy to tame inflammation

Abstract

Single-target inhibition is an unsatisfactory therapeutic option to treat multifactorial pathologies, brought into limelight ‘paradox of inflammation’ beside dearth of innovation, rationalizes a shift toward ‘multiple-target’ design concept in anti-inflammatory research field. To improvise, two platform strategies, drugs mixture or multitarget drugs, are plausible. Dual cyclooxygenase/lipoxygenase inhibitor ‘licofelone’ developed after the backfire of rofecoxib due to safety concerns has fetched first light of triumph of the latter strategy. As hitting multiple targets in restraint is perhaps more viable strategy rather than single target, this review, outlines the most germane multiple target agents of synthetic and natural origin placing clear advantage in favors of multitarget strategy as real therapeutic solution for inflammation.