Affiliation:
1. Graduate Entry Medical School, University of Limerick, Limerick, Republic of Ireland
Abstract
COVID-19 has now been declared a pandemic and new treatments are urgently needed as we enter a phase beyond containment. Developing new drugs from scratch is a lengthy process, thus impractical to face the immediate global challenge. Drug repurposing is an emerging strategy where existing medicines, having already been tested safe in humans, are redeployed to combat difficult-to-treat diseases. While using such repurposed drugs individually may ultimately not yield a significant clinical benefit, carefully combined cocktails could be very effective, as was for HIV in the 1990s; the urgent question now being which combination.
Reference20 articles.
1. Discovery and development of safe-in-man broad-spectrum antiviral agents
2. DrugVirus. Broad-spectrum antiviral agents (BSAAs) and viruses they inhibit (2020). https://drugvirus.info/
3. Common Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis
4. NIH Clinical Trials. A prospective/retrospective,randomized controlled clinical study of antiviral therapy in the 2019-nCoV pneumonia (2020). https://clinicaltrials.gov/ct2/show/NCT04255017
5. NIH Clinical Trials. Mild/moderate 2019-nCoV remdesivir RCT (2020). https://clinicaltrials.gov/ct2/show/NCT04252664
Cited by
101 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献