Ternary system of sultamicillin tosylate with hydroxypropyl-β-cyclodextrin and L-arginine: susceptibility against methicillin-resistant Staphylococcus aureus

Abstract

Aim: This study investigated the effect of complex formation between sultamicillin tosylate (ST), hydroxypropyl-β cyclodextrin (HP-βCD) and L-arginine (ARG). Materials & methods: The kneading method was used to prepare the complexes, which were then characterized using SEM, DSC, FT-IR, HPLC, saturation solubility and dissolution studies. The complexes' antibacterial activity against MRSA (ATCC®-43300TM) was evaluated using ZOI and MIC. Results: Solubility was enhanced in the binary and ternary complexes compared with ST (p < 0.001). MIC and ZOI showed that both complexes have increased antibacterial activity compared with ST (p < 0.001) against MRSA. Conclusion: As a result, the inclusion complex of ST with HP-βCD and ARG can be used to improve the physicochemical properties of ST while also improving antibacterial efficacy against MRSA infections.