Characterization and antifungal activity of chlorhexidine:β-cyclodextrin inclusion complexes

Author:

Schoeffel Amanda Cristina1ORCID,Morikava Francine Sumie1ORCID,Urban Amanda Migliorini2ORCID,Novatski Andressa3ORCID,Moraes Gustavo Simão1ORCID,Matioli Graciette4ORCID,Ferrari Priscileila Colerato2ORCID,Neppelenbroek Karin Hermana5ORCID,Farago Paulo Vitor2ORCID,Urban Vanessa Migliorini1ORCID

Affiliation:

1. Department of Dentistry, State University of Ponta Grossa (UEPG), Ponta Grossa, PR, 84030-900, Brazil

2. Department of Pharmaceutical Sciences, State University of Ponta Grossa (UEPG), Ponta Grossa, PR, 84030-900, Brazil

3. Department of Physics, State University of Ponta Grossa (UEPG), Ponta Grossa, PR, 84030-900, Brazil

4. Department of Pharmacy, State University of Maringá (UEM), Maringá, PR, 87020-900, Brazil

5. Department of Prosthodontics & Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, 17012-901, Brazil

Abstract

Aim: This study aimed to develop, characterize and analyze the antifungal activity of chlorhexidine:β-cyclodextrin inclusion complexes (Chx:βCD). Materials & methods: Chx:βCD were characterized by physicochemical techniques and the susceptibility of nine Candida strains was assessed. The inhibition of Candida albicans biofilm growth was evaluated in a denture material modified with the incorporation of Chx:βCD. Results: Chx was better complexed in 1:2 molar ratio by freeze-drying. Chx:βCD presented antifungal activity against all Candida strains. When incorporated into the denture material, Chx:βCD showed better antifungal activity, as it required about 7.5% of Chx concentration compared with the raw Chx for 14 days. Conclusion: The improved characteristics of Chx:βCD can result in new formulations to treat oral candidiasis and denture stomatitis.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

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