Polyhydroquinoline derivatives for diabetic management: synthesis, <i>in vitro</i> and <i>in silico</i> approaches-Reference-Cited by-同舟云学术

Polyhydroquinoline derivatives for diabetic management: synthesis, in vitro and in silico approaches

Published:2023-12 Issue:23 Volume:15 Page:2195-2208
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Talab Faiz¹,Zainab ²,Alam Aftab¹,Ali Mumtaz¹,Rehman Najeeb Ur³,Ullah Saeed³,Halim Sobia Ahsan³,Islam Mohammad Shahidul⁴,Khan Ajmal³,Latif Abdul¹,Ayaz Muhammad¹,Al-Ghafri Ahmed³,Al-Harrasi Ahmed³,Ahmad Manzoor¹^ORCID

Affiliation:

1. Department of Chemistry, University of Malakand, PO Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan

2. College of Chemistry & Materials Science, Hebei Normal University, Shijiazhuang, 050024, China

3. Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, 616, Oman

4. Department of Chemistry, College of Science, King Saud University, PO Box 2455, Riyadh, 11451, Saudi Arabia

Abstract

Background: Medication used to treat Type 2 diabetes by decreasing the absorption of carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline derivatives have attracted interest as excellent antidiabetic agents. Methods: Polyhydroquinoline derivatives (1–17) were synthesized and tested for in vitro α-glucosidase inhibitory activity. Results: All the synthesized compounds exhibited excellent to good inhibitory activity, having IC50 values from 1.23 ± 0.03 to 73.85 ± 0.61 μM, compared with the standard drug, acarbose. The binding mechanism of these derivatives with α-glucosidase was deduced by docking studies and indicated that a slight variation in the orientation of compounds, affects their binding capability. Conclusion: In order to find new antidiabetic drugs, this study has discovered prospective lead candidates.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2023-0232

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