Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds-Reference-Cited by-同舟云学术

Novel antimicrobial iodo-dihydro-pyrrole-2-one compounds

Published:2023-08 Issue:15 Volume:15 Page:1369-1391
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Al-Matarneh Cristina M¹²^ORCID,Nicolescu Alina³,Marinas Ioana C¹^ORCID,Chifiriuc Mariana C¹,Shova Sergiu⁴,Silion Mihaela⁵,Pinteala Mariana²

Affiliation:

1. Research Institute of the University of Bucharest-ICUB, 91-95 Spl. Independentei, Bucharest, 050095, Romania

2. Center of Advanced Research in Bionanoconjugates & Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi, 700487, Romania

3. NMR Laboratory “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi, 700487, Romania

4. Department of Inorganic Polymers “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, 41A Grigore Ghica Voda Alley, Iasi, 700487, Romania

5. Physics of Polymers & Polymeric Materials Department, “Petru Poni” Institute of Macromolecular Chemistry, 41A Grigore Ghica Voda Alley, Iasi, 700487, Romania

Abstract

Aim: A series of new hybrid molecules with two iodine atoms on the sides were synthesized. Methods: A one-pot, two-component method with trifluoroacetic acid as an effective catalyst to obtain dihydro-pyrrol-2-one compounds was developed. Short reaction times, a cheap catalyst, high yields and clean work-up are benefits of this method. Results: The chemical structures of the newly synthesized compounds were verified through spectroscopic techniques. Their antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans was tested in vitro. Conclusion: NC- and OH- radicals confer broad-spectrum antimicrobial activity, including against Gram-positive and Gram-negative bacteria and yeasts. Compounds 3g >7 and >9 were most active on the two bacterial species, while 3l >9 and >3i were most active against the fungal strain.

Funder

ICUB Fellowship for Young Researchers

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2023-0121

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