Synthesis of 1,3,4-oxadiazoles with 4-methoxynaphthalene ring: discovering new compounds with antimicrobial activity-Reference-Cited by-同舟云学术

Synthesis of 1,3,4-oxadiazoles with 4-methoxynaphthalene ring: discovering new compounds with antimicrobial activity

Published:2023-12 Issue:24 Volume:15 Page:2239-2255
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Frederico Rozada Andrew Matheus¹^ORCID,Vilugron Rodrigues-Vendramini Franciele Abigail²^ORCID,Kioshima Erika Seki²^ORCID,Sampiron Eloísa Gibin³^ORCID,de Lima Scodro Regiane Bertin⁴^ORCID,Caleffi-Ferracioli Katiany Rizzieri⁴^ORCID,Vicente Seixas Flávio Augusto⁵^ORCID,Basso Ernani Abicht¹^ORCID,Freitas Gauze Gisele de¹^ORCID

Affiliation:

1. Chemistry Department, State University of Maringá, PR, 87020-900, Brazil

2. Department of Clinical Analysis & Biomedicine, Laboratory of Medical Mycology, State University of Maringá, Maringá, PR, 87020-900, Brazil

3. Postgraduate Program in Health Sciences, State University of Maringa, Maringá, PR, 87020-900, Brazil

4. Department of Clinical Analysis & Biomedicine, State University of Maringá, Maringá, PR, 87020-900, Brazil

5. Department of Technology, State University of Maringá, Umuarama, PR, 87506-370, Brazil

Abstract

Background: Paracoccidioidomycosis (PCM) is a systemic infection caused by Paracoccidioides spp. ( Pb). PCM can be associated or clinically confused with tuberculosis (TB), another pulmonary infection, caused by Mycobacterium tuberculosis ( Mtb). Futhermore, the long treatment time of TB and PCM and the cases of TB drug resistance impose difficulties for the cure of these diseases. Results: New 1,3,4-oxadiazoles containing the 4-methoxynaphthalene ring were synthesized and their antimicrobial activity was evaluated against Pb and Mtb. The derivative 6n (with 2-hydroxy-5-nitrophenyl subunit) is the most promising of the series. Conclusion: The 1,3,4-oxadiazole 6n can be used as a prototype drug candidate, with anti- Pb and anti- MTb activities, showing a broad-spectrum profile for the treatment of both pulmonary infections.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2023-0153

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