The Zn(S-pr-thiosal)2 complex attenuates murine breast cancer growth by inducing apoptosis and G1/S cell cycle arrest-Reference-Cited by-同舟云学术

The Zn(S-pr-thiosal)2 complex attenuates murine breast cancer growth by inducing apoptosis and G1/S cell cycle arrest

Published:2020-05 Issue:10 Volume:12 Page:897-914
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Benazic Sasa¹,Silconi Zana Besser²,Jevtovic Andra³⁴,Jurisevic Milena³⁵,Milovanovic Jelena³⁶,Mijajlovic Marina⁵,Nikolic Milos⁵,Kanjevac Tatjana⁷,Potočňák Ivan⁸,Samoľová Erika⁸,Ratkovic Zoran R⁹,Radic Gordana⁵,Milovanovic Marija³,Pantic Jelena³,Arsenijevic Nebojsa³,Radosavljevic Gordana D³

Affiliation:

1. Department of Transfusiology, Pula General Hospital, Pula, 52100, Croatia

2. Department of Cytology, Pula General Hospital, Pula, 52100, Croatia

3. Center for Molecular Medicine & Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia

4. Department of Otorhinolaryngology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia

5. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia

6. Department of Histology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia

7. Department of Dentistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, 34000, Serbia

8. Institute of Chemistry, Faculty of Science, P.J. Šafárik University in Košice, Košice, 34000, Slovakia

9. Department of Chemistry, Faculty of Science, University of Kragujevac, Kragujevac, 34000, Serbia

Abstract

Aim: We investigated the antitumor effects of zinc(II) complex with S-propyl thiosalicylic acid [Zn( S-pr-thiosal)2] in 4T1 murine breast cancer model. Results: The Zn( S-pr-thiosal)2 complex reduced primary tumor growth in vivo and induced tumor cell apoptosis. The Zn( S-pr-thiosal)2 complex disrupted the balance between pro- and antiapoptotic Bcl-2 family members in 4T1 cells and induced G1/S cell cycle arrest. The Zn( S-pr-thiosal)2 complex increased the percentage of p16, p21 and p27 positive 4T1 cells. There was a significantly decrease in expression of STAT3 and its targets c-Myc and cyclin D3 in 4T1 cells treated with the Zn( S-pr-thiosal)2 complex thus contributing to G1/S cell cycle arrest and/or apoptosis. Conclusion: Our data suggest that the Zn( S-pr-thiosal)2 complex restricted tumor growth through induction of mitochondrial-driven apoptosis and suppression of cell cycle progression.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2019-0215

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