Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects-Reference-Cited by-同舟云学术

Neurochemical regulators of food behavior for pharmacological treatment of obesity: current status and future prospects

Published:2020-10 Issue:20 Volume:12 Page:1865-1884
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Vardanyan Gayane Sargis¹^ORCID,Harutyunyan Hasmik Samvel¹^ORCID,Aghajanov Michail Iosif¹^ORCID,Vardanyan Ruben Sargis²^ORCID

Affiliation:

1. Department of Biochemistry, Yerevan State Medical University, 2 Koryun str., Yerevan, 0025, Armenia

2. Department of Chemistry & Biochemistry, University of Arizona, 1306 East University Boulevard, PO Box 210041, Tucson, AZ 85721, USA

Abstract

In recent decades, obesity has become a pandemic disease and appears to be an ultimate medical and social problem. Existing antiobesity drugs show low efficiency and a wide variety of side effects. In this review, we discuss possible mechanisms underlying brain–gut–adipose tissue axis, as well as molecular biochemical characteristics of various neurochemical regulators of body weight and appetite. Multiple brain regions are responsible for eating behavior, hedonic eating and food addiction. The existing pharmacological targets for treatment of obesity were reviewed as well.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2019-0361

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