Design of submicron and nanoparticle delivery systems using supercritical carbon dioxide-mediated processes: an overview

Abstract

Supercritical carbon dioxide technology is an environmentally benign technique that allows precise control of particle morphology, while minimizing organic solvent use for a wide variety of biomedical and pharmaceutical applications. Supercritical carbon dioxide processes have benefits over the conventional particle formation methods in terms of improved control, flexibility and operational ease. This article gives an insight into a variety of supercritical fluid techniques relevant to drug formulation, recent advances and novel applications in the field of controlled delivery. These new methods have been designed to alleviate the scaling-up of the traditional methods for nanoparticle formulation either in the form of polymeric scaffolds, impregnation or nanoencapsules using a simple one-step process to produce micron-size particles.