Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacy

Author:

Spencer Drew A1,Young Jacob S2,Kanojia Deepak2,Kim Julius W2,Polster Sean P2,Murphy Jason P2,Lesniak Maciej S2

Affiliation:

1. Department of Neurosurgery, Loyola University Medical Center, 2160 S. 1st Avenue, Maywood, IL 60153, USA

2. The Brain Tumor Center, The University of Chicago, 5841 S. Maryland Avenue, MC 3026, Chicago, IL 60637, USA

Abstract

Malignant glioma is a relentless burden to both patients and clinicians, and calls for innovation to overcome the limitations in current management. Glioma therapy using viruses has been investigated to accentuate the nature of a virus, killing a host tumor cell during its replication. As virus mediated approaches progress with promising therapeutic advantages, combination therapy with chemotherapy and oncolytic viruses has emerged as a more synergistic and possibly efficacious therapy. Here, we will review malignant glioma as well as prior experience with oncolytic viruses, chemotherapy and combination of the two, examining how the combination can be optimized in the future.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

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