Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story
Author:
Affiliation:
1. Ascendance Biotechnology, Inc., Medford, MA, USA
2. Pfizer Inc., Groton, CT, USA
Abstract
Publisher
Future Science Ltd
Subject
Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry
Link
http://www.future-science.com/doi/pdf/10.4155/bio-2016-0094
Reference30 articles.
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2. Metabolism and excretion of loratadine in male and female mice, rats and monkeys
3. Disposition of loratadine in healthy volunteers
4. Metabolism of Loratadine and Further Characterization of Its In Vitro Metabolites
5. Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine
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