Multiple myeloma: therapeutic delivery of antibodies and aptamers

Author:

Pujol-Navarro Neret12ORCID,Al Qaraghuli Mohammed M12ORCID,Kubiak-Ossowska Karina3ORCID,Alsaadi Manal M4ORCID,Horne Gillian A5ORCID,Soutar Richard L6ORCID,Paspali Elpiniki1ORCID,Ferro Valerie A2ORCID,Williams Mark TS7ORCID,Mulheran Paul A1ORCID

Affiliation:

1. Department of Chemical Engineering, University of Strathclyde, Glasgow, G1 1XL, UK

2. Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, G4 0RE, UK

3. ARCHIE-WeSt, Department of Physics, University of Strathclyde, Glasgow, G4 0NG, UK

4. Department of Industrial Pharmacy, Faculty of Pharmacy, University of Tripoli, PO Box 13645, Tripoli, Libya

5. Paul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, G12 0YN, UK

6. Department of Haematology, Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, UK

7. Department of Biological & Biomedical Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, UK

Abstract

Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current chemotherapy-based regimes are insufficient, as most patients relapse and develop therapy resistance. This review focuses on current novel antibody- and aptamer-based therapies aiming to overcome current therapy limitations, as well as their respective limitations and areas of improvement. The use of computer modeling methods, as a tool to study and improve ligand-receptor alignments for the use of novel therapy development will also be discussed, as it has become a rapid, reliable and comparatively inexpensive method of investigation.

Funder

Biotechnology and Biological Sciences Research Council,

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3