Potential of targeting TGF-β for organ transplant patients-Reference-Cited by-同舟云学术

Potential of targeting TGF-β for organ transplant patients

Published:2013-03 Issue:3 Volume:5 Page:281-289
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Iwashima Makio¹²,Love Robert²³

Affiliation:

1. Department of Microbiology & Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA.

2. VanKampen Cardiopulmonary Research Laboratory, Stritch School of Medicine, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA

3. Department of Surgery, Medical College of Wisconsin, USA

Abstract

TGF-β was originally considered as an immunoregulatory cytokine, but accumulating data demonstrate that it also plays a critical role in development of effector immunity. Since TGF- β has a potent ability to alter immune responses, modulation of the TGF-β pathway for treatment of transplantation patients could be effective if carried out in a target selective manner. This review will focus on the role of TGF-β in T cell differentiation and discuss the prospect of TGF-β as the therapeutic target of lung transplantation acceptance.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.12.215

Reference80 articles.

1. Regulatory immune cells in transplantation

2. Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy

3. Lack of Improvement in Renal Allograft Survival Despite a Marked Decrease in Acute Rejection Rates Over the Most Recent Era

4. Immunosuppression for Lung Transplantation

5. Immunosuppressive Drugs in Kidney Transplantation

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Regulatory role of T helper 9/interleukin-9: Transplantation view;Heliyon;2024-02

2. Lessons from transmissible cancers for immunotherapy and transplant;Immunological Medicine;2021-12-28

3. Cytokines in Liver Transplantation;Cytokine;2021-12

4. A high concentration of TGF-β correlates with opportunistic infection in liver and kidney transplantation;Human Immunology;2021-06

5. RGD‐binding integrins and TGF‐β in SARS‐CoV‐2 infections – novel targets to treat COVID‐19 patients?;Clinical & Translational Immunology;2021-01