Ferrocene-based antimalarials

Author:

Roux Clément1,Biot Christophe2

Affiliation:

1. Izon Science, Begbroke Science Park, Oxford, OX5 1PF, UK

2. Université Lille Nord de France, Université Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, IFR 147, 59650 Villeneuve d’Ascq Cédex, France.

Abstract

Resistance to commercially available antimalarial drugs is a public health problem. Since the end of the last century, no new antimalarial drugs have been introduced into clinical practice, and new drug development has been quite disappointing. There is therefore a real need to develop new class of antimalarial drugs that could be used alone or in combination. This review describes the development and recent advances on the preparation of ferrocenic compounds as a new class of antimalarial agents with potential for clinical development.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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