Physical and pharmacokinetic characterization of Soluvec™, a novel, solvent-free aqueous ivermectin formulation-Reference-Cited by-同舟云学术

Physical and pharmacokinetic characterization of Soluvec™, a novel, solvent-free aqueous ivermectin formulation

Published:2023-06 Issue:6 Volume:14 Page:391-399
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Mandalaywala Richa¹,Rana Azhar¹,Ramos Aubrey L¹,Sampson Peter²,Ashkenas John³^ORCID

Affiliation:

1. Mountain Valley MD, 260 Edgeley Blvd – Unit 4, Concord, Ontario, L4K 3Y4, Canada

2. IntrinsiChem Consulting Inc., Oakville, Ontario, L6M 4A2, Canada

3. EquiPoise Communication, 491 Brunswick Ave, Toronto, Ontario, M5R 2Z6, Canada

Abstract

Purpose: To describe application of the Quicksol™ solvent-free approach to solubilize ivermectin (IVM). Methods: Lyophilized IVM complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) was resolubilized in aqueous polysorbate-80, generating Soluvec™. Lyophilizate was examined by Fourier-transform infrared spectroscopy and differential scanning calorimetry; Soluvec, by dynamic light scattering. Pharmacokinetics was evaluated in dogs allocated to subcutaneous (SC) or intramuscular (IM) Soluvec or oral IVM. Results: IVM in Soluvec was tightly bound by HPβCD, forming nearly monodisperse 28 nm particles with solubility ∼2500-times that of free IVM. SC and IM Soluvec increased IVM exposure, peak IVM and extended duration of IVM exposure, versus oral dosing. Conclusion: The Quicksol method generated Soluvec, a concentrated aqueous parenteral IVM formulation with pharmacokinetic properties suitable for veterinary or human use.

Funder

Mountain Valley MD

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

https://www.future-science.com/doi/pdf/10.4155/tde-2023-0021

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