In situ gastric floating gel of atazanavir sulphate for sustained release: formulation, optimization and evaluation

Author:

Masareddy Rajashree1,Sandure Pradnya1,Patil Archana1ORCID,Gaude Yadishma1,Patil Arpana1

Affiliation:

1. Department of Pharmaceutics, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education & Research, Belagavi, Karnataka, 590010, India

Abstract

Aim: Atazanavir sulphate belongs to BCS class II drug, its oral bioavailability is limited due to its rapid first-pass metabolism and P-gp efflux. Materials & methods: The in situ floating gel using the complexed drug was prepared by ion gelation method and optimized the formulation as per 32 full factorial design. Results: Floating lag time of optimized formulation was found to be 18 s and percentage drug release of 94.18 ± 0.18 % at the end of 16 h. The concentration of gelling polymer affects drug release and a floating lag time and vice versa. Conclusion: In situ floating gel of atazanavir sulphate was found promising to sustain drug release due to an increased gastric residence time, which leads to enhanced potential therapy.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

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