Influence of iontophoresis on delivery of NSAID-loaded deformable liposomal dispersions: in vitro and in vivo evaluation

Author:

Vanaja Kenchappa123ORCID,S Salwa3,Shivakumar Hagalavadi Nanjappa34ORCID,Murthy S. Narasimha35

Affiliation:

1. College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore

2. College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA

3. Institute for Drug Delivery & Biomedical Research, Bangalore, India

4. Basic Science Research Centre, K.L.E. College of Pharmacy, Bengaluru, India

5. Topical testing Laboratory, 9 Industrial Park Drive Oxford, MS 38655, USA

Abstract

Aim: Negatively charged deformable liposomes (DL) of ketoprofen were formulated to enhance transdermal delivery of ketoprofen (KP) under the influence of iontophoresis for intraarticular delivery. Methods: Conventional and deformable KP liposomes were prepared using thin film hydration, characterized and intraarticular delivery of KP was evaluated using Sprague-Dawley rats. Results: Vesicles displayed entrapment efficiency (>71%); zeta potential <-25 mV; size between 152.4 ± 12.42 nm to 220.4 ± 6.22 nm, KP-DL were stable under iontophoresis. Conventional and deformable liposomes exhibited relatively higher iontophoretic flux values than passive flux; Iontophoretic delivery enhanced KP availability in the synovial fluid (1.34 ± 0.12 μg.h/ml) fourfold over passive delivery (0.329 ± 0.15 μg.h/ml). Conclusion: Iontophoretic mediated transport of deformable liposomes could improve transdermal delivery of ketoprofen into the synovial joints than conventional liposomes.

Funder

Department of Biotechnology, BIRAC, India

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

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