Physicochemical property trends of marketed prodrugs-Reference-Cited by-同舟云学术

Physicochemical property trends of marketed prodrugs

Published:2013-02 Issue:2 Volume:4 Page:225-237
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Landis Margaret S¹

Affiliation:

1. Pfizer Global Research & Development, Pharmaceutical Sciences-Research Formulations, Eastern Point Road, Groton, CT 06340, USA.

Abstract

Many prodrug reviews describe specific examples of the successful application of prodrug technology to produce blockbuster drugs, such as simvastatin, omeprazole, acyclovir and enalapril. These reviews are helpful to understand the previous success stories and case histories of prodrug technology. The aim of the current review seeks to more clearly define quantitative trends in the changes in the physicochemical property parameters between the successful prodrug and the active parent molecule. This information can serve to guide medicinal chemists toward more successful pharmaceutical prodrugs in the future.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

http://www.future-science.com/doi/pdf/10.4155/tde.12.150

Reference108 articles.

1. StellaVJ, Borchardt RT, Hageman MJ, Oliyai R, Maag H, Tilley J.Prodrugs: Challenges and Rewards. Springer Inc., New York, NY, USA (2007).

2. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

3. Prodrugs as therapeutics

4. Pharmacokinetics of acemetacin and its active metabolite indomethacin in rats during acute hepatic damage and liver regeneration

5. Prodrug Approach for Increasing Cellular Glutathione Levels

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Monitoring of the Antipsychotic Therapy Effectiveness;Psikhiatriya;2023-01-10

2. Physicochemical Properties of Zwitterionic Drugs in Therapy;ChemMedChem;2020-06-09

3. Selective Activation of Transition-Metal Complexes in Medicine;Encyclopedia of Inorganic and Bioinorganic Chemistry;2018-09-14

4. Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors;PLOS ONE;2018-09-07

5. Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents;Future Medicinal Chemistry;2017-10