Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation-Reference-Cited by-同舟云学术

Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation

Published:2019-05-01 Issue:5 Volume:10 Page:281-293
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Chellappan Dinesh Kumar¹^ORCID,Yee Neoh Jia²,Kaur Ambar Jeet Singh Bhalqish Jeet²,Panneerselvam Jithendra³,Madheswaran Thiagarajan³,Chellian Jestin¹,Satija Saurabh⁴,Mehta Meenu⁴,Gulati Monica⁴,Gupta Gaurav⁵^ORCID,Dua Kamal⁶⁷

Affiliation:

1. Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia 57000

2. School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia 57000

3. Department of Pharmaceutical Technology, International Medical University, Kuala Lumpur, Malaysia 57000

4. School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road (NH-1), Phagwara-144411, Punjab, India

5. School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, 302017, Jaipur, India

6. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia

7. Priority Research Centre for Healthy Lungs, School of Biomedical Sciences & Pharmacy, The University of Newcastle, Callaghan, Australia

Abstract

Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

https://www.future-science.com/doi/pdf/10.4155/tde-2019-0019

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