Recent advances in LC–MS/MS analysis of Δ9-tetrahydrocannabinol and its metabolites in biological matrices-Reference-Cited by-同舟云学术

Recent advances in LC–MS/MS analysis of Δ9-tetrahydrocannabinol and its metabolites in biological matrices

Published:2013-11 Issue:21 Volume:5 Page:2713-2731
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Ferreirós Nerea¹

Affiliation:

1. pharmazentrum grankfurt/ZAFES, Institute of Clinical Pharmacology, Uniklinik der J. W. Goethe Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.

Abstract

Cannabis is the most widely used illicit drug in the world. The pharmacological properties of Δ9-tetrahydrocannabinol also make it a promising molecule in the treatment of different pathologies. Understanding the PKs and PDs of this drug requires the determination of the concentration of Δ9-tetrahydrocannabinol and metabolites in biological matrices. For this purpose many analytical methodologies using mass spectrometric detection have been developed. In recent years, LC–MS/MS has become the gold standard in analysis of tetrahydrocannabinol and its metabolites due to the high selectivity and sensitivity, but above all, due to the ability to determine free and conjugate analytes in one run.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.13.218

Reference100 articles.

1. History of cannabis as a medicine: a review

2. Cannabinoid pharmacology: the first 66 years

3. Chemical constituents of marijuana: The complex mixture of natural cannabinoids

4. Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

5. Evolution of the Content of THC and Other Major Cannabinoids in Drug-Type Cannabis Cuttings and Seedlings During Growth of Plants*

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