Author:
Gordeychuk I. V.,Gancharova О. S.,Gulyaev S. A.,Gulyaeva Т. V.,Zhitkevich A. S.,Avdoshina D. V.,Moroz A. V.,Lunin A. S.,Sotskova S. E.,Korduban E. A.,Tukhvatulin A. I.,Bayurova E. O.,Ishmukhametov A. A.
Abstract
Common marmoset (Callithrix jacchus, CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of CMs. We also establish the reference values of the main complete blood count and serum chemistry parameters evaluated during preclinical trials of immunobiological products and describe the histological characteristics of CM lymphoid organs during the development of post-vaccination immune response. We show that CMs bred in laboratory conditions excluding background infectious pathology are a relevant model that allows for a high degree of reliability in characterizing the safety and immunogenicity profile of antiviral vaccines during preclinical trials.
Reference17 articles.
1. Heijmans C.M.C., de Groot N.G., Bontrop R.E. // Int. J. Immunogenet. 2020. V. 47. № 3. P. 243–260.
2. ‘t Hart B.A., Abbott D.H., Nakamura K., Fuchs E. // Drug Discov. Today. 2012. V. 17. № 21–22. P. 1160–1165.
3. Bayurova E., Zhitkevich A., Avdoshina D., Kupriyanova N., Kolyako Y., Kostyushev D., Gordeychuk I. // Cells. 2023. V. 12. № 16. P. 2020.
4. Tardif S.D., Smucny D.A., Abbott D.H., Mansfield K., Schultz-Darken N., Yamamoto M.E. // Comparative Medicine. 2003. V. 53. № 4. P. 364–368.
5. Antunes S.G., de Groot N.G., Brok H., Doxiadis G., Menezes A.A., Otting N., Bontrop R.E. // Proc. Natl. Acad. Sci. USA. 1998. V. 95. № 20. P. 11745–11750.