CELLULOSE NANOCRYSTAL-INCORPORATED CO-PROCESSED EXCIPIENT IN TABLET FORMULATION

Abstract

The objective of the current work is to develop a new co-processed excipient based on cellulose nanocrystals and investigate its pharmaceutical excipient properties. Cellulose nanocrystals were isolated from the pseudostem of Musa balbisiana, following TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy)-mediated oxidation, and then co-processed with potato starch by the wet granulation method. Physicochemical properties, including the flow property, consolidation characteristics and rate of consolidation, were investigated, and a Kawakita plot was also generated. The compressibility, compactibility and tabletability of the novel excipient were determined. The equivalent circle diameter of the excipient particle was calculated as 4.09±0.90 μm, exhibiting a fair to passable flow property. The mean yield pressure from the Heckel plot was found to be 82.64 MPa, indicating its ability to undergo plastic deformation at relatively lower compression pressures. When compared to sodium starch glycolate, a standard tablet disintegrant, the cellulose nanocrystal-based co-processed excipient produced better dissolution of the model drug paracetamol.