Peculiarities of safety assessment of nanoscale materials (literature review)

Author:

Leonenko O.B.1,Leonenko N.S.1

Affiliation:

1. State Institution “Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine

Abstract

The manifestation of the biological effects of nanoscale materials depends on many initial states as the NPs themselves (on their size and structural organization, on the physical nature, method of production and method of surface modification), and on the biological model under test and the following interfaces “nano-bio” after penetration into tissues and blood, so they are not predictable, and target organs and mechanisms of development of toxic effect can be varied, which is the basis for urgent need to improve scientific approaches to the assessment of toxicity and danger of nanomaterials. Key Words: nanoscale materials, hazard, features of evaluation.

Publisher

L. I. Medved Research Center of Preventive Toxicology, Food and Chemical Safety

Reference49 articles.

1. Shang L, Nienhaus K, Nienhaus GU. Engineered nanoparticles interacting with cells: size matters // J. Nanobio-technology. – 2014. – Feb 3;12:5. doi: 10.1186/1477- 3155-12-5.

2. Trofimova S. A. Methodological approaches to assessing the biological effect of nanomaterials // Journal of Biomedical Technologies. – 2015. – №1. – С. 38–44. DOI: 10.15393/ j6.art.2015.3283.

3. Leonenko N.S., Demetskaya O.V., Leonenko O.B. Features of physicochemical properties and toxic action of nanomaterials – to the problem of estimation of their dangerous impact on living organisms (literature review) // Modern problems of toxicology. – 2016. – 14. – P. 64–76.

4. Krasochko P. Assessment of the interaction of silver nanoparticles with transplantable MDBC cells / P. Kra-sochko, S. Chizhik, A. Khudoley, A. Stankut, E.S. Drozd // Veterinary Biotechnology. – 2012. – №21. – P. 261–265.

5. Leonenko N., Demetskaya O., Leonenko O. Methodological approaches to the evaluation of the toxicity and danger of nanomaterials //Environment and Health. 2017. – №3. – P.9–13.

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