The influence of omega-3 polynenasic fatty acids on the pathogenetic lines of arterial hypertension in the person with abdominal obesity

Abstract

Hypertriglyceridemia is a characteristic feature of dyslipidemia in hypertension in patients with concomitant abdominal obesity. These individuals constitute an increased risk of cardiovascular complications, so optimizing their treatment is extremely important medical problem. The aim is to study the dynamics of the major lipid spectrum of the blood vessels and endothelial function as a marker of atherosclerosis, when you connect to the drug ω-3 polyunsaturated fatty acids to the standard combination of antihypertensive and lipid-lowering therapy in patients with hypertension and abdominal obesity. The analysis of the dynamics of lipidohramy and vascular endothelial function in patients with essential hypertension and abdominal obesity during the 6-month standard (basic) antihypertensive (lisinopril, amlodipine) and lipid-lowering therapy (atorvastatin) (group I) and accession thereto ω-3 polyunsaturated fatty acids (group II). When analyzing the results of 6 months of treatment in the studied patient groups in triglycerides reduction was significantly more pronounced when using combination antihypertensive and lipid-lowering therapy (-40,9+3,1% in group II and -22,7+2,3% in group I, p<0,001). Also in group II was marked significantly greater increase in HDL cholesterol (38,6+2,5% in group II and 28,7+2,6% in group I, p<0,05) and improved endothelium vasodilation (9,86+0,28% in group II and 6,8+0,23%, p<0,01). Thus, in patients with hypertension and concomitant abdominal obesity observed significant dyslipidemia, a characteristic feature of which is hypertriglyceridemia. Joining the standard antihypertensive and lipid-lowering therapy ω-3 polyunsaturated fatty acids contributes significantly more effective normalization of triglycerides. For persons with hypertension and concomitant abdominal obesity is characterized by endothelial dysfunction and significant additional purpose to standard therapy ω-3 polyunsaturated fatty acids leads to a significant improvement. Key Words: arterial hypertension, obesity, dyslipidemia, endothelial function, free-3 polyunsaturated fatty acids.