Evolutionary trends of alternative splicing-Reference-Cited by-同舟云学术

Evolutionary trends of alternative splicing

Published:2024-06-12 Issue: Volume: Page:
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Author:

de la Fuente Rebeca¹^ORCID,Díaz-Villanueva Wladimiro²^ORCID,Arnau Vicente²^ORCID,Moya Andrés²³⁴^ORCID

Affiliation:

1. Austral Center for Scientific Research (CADIC-CONICET)

2. Institute of Integrative Systems Biology (I2Sysbio), University of Valencia and Spanish National Research Council (CSIC)

3. Foundation for the Promotion of Sanitary and Biomedical Research of the Valencian Community (FISABIO)

4. Center for Biomedical Research in Epidemiology and Public Health Network (CIBEResp)

Abstract

Alternative splicing is the post-transcriptional mechanism by which many different isoforms are generated from a single gene, contributing to increasing spatio-temporal transcriptome complexity. We propose a novel genome-level measure of alternative splicing, which associates it with a single value for each species. Thus, a comparative analysis of species spanning the whole tree of life has revealed certain evolutionary trends in alternative splicing, prevalence in specific lineages, and relation to genome compositional structures.

Publisher

eLife Sciences Publications, Ltd

Link

https://elifesciences.org/reviewed-preprints/94802v1/pdf

Reference51 articles.

1. Global analysis of exon creation versus loss and the role of alternative splicing in 17 vertebrate genomes;RNA,2007

2. Comparative genomics and evolution of proteins involved in RNA metabolism;Nucleic Acids Research,2002

3. Endosymbiosis and Eukaryotic Cell Evolution;Current Biology,2015

4. The Evolutionary Landscape of Alternative Splicing in Vertebrate Species;Science,2012

5. Genome Size Evolution in Plants;In: The Evolution of the Genome Academic Press,2005