Cell type specificity of neurovascular coupling in cerebral cortex-Reference-Cited by-同舟云学术

Cell type specificity of neurovascular coupling in cerebral cortex

Published:2016-05-31 Issue: Volume:5 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Uhlirova Hana¹,Kılıç Kıvılcım²,Tian Peifang²³,Thunemann Martin¹,Desjardins Michèle¹,Saisan Payam A²,Sakadžić Sava⁴,Ness Torbjørn V⁵,Mateo Celine⁶,Cheng Qun²,Weldy Kimberly L²,Razoux Florence²,Vandenberghe Matthieu¹⁷,Cremonesi Jonathan A⁸,Ferri Christopher GL²,Nizar Krystal⁹,Sridhar Vishnu B¹⁰,Steed Tyler C⁹,Abashin Maxim¹¹,Fainman Yeshaiahu¹¹,Masliah Eliezer²,Djurovic Srdjan¹²¹³^ORCID,Andreassen Ole A⁷,Silva Gabriel A¹⁰¹⁴,Boas David A⁴,Kleinfeld David⁶¹¹¹⁵,Buxton Richard B¹,Einevoll Gaute T⁵¹⁶^ORCID,Dale Anders M¹²,Devor Anna¹²⁴^ORCID

Affiliation:

1. Department of Radiology, University of California, San Diego, La Jolla, United States

2. Department of Neurosciences, University of California, San Diego, La Jolla, United States

3. Department of Physics, John Carroll University, University Heights, United States

4. Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, United States

5. Department of Mathematical Sciences and Technology, Norwegian University of Life Sciences, Ås, Norway

6. Department of Physics, University of California, San Diego, La Jolla, United States

7. NORMENT, KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, University of Oslo, Oslo, Norway

8. Biology Undergraduate Program, University of California, San Diego, La Jolla, United States

9. Neurosciences Graduate Program, University of California, San Diego, La Jolla, United States

10. Department of Bioengineering, University of California, San Diego, La Jolla, United States

11. Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, United States

12. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway

13. NORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway

14. Department of Ophthalmology, University of California, San Diego, La Jolla, United States

15. Section of Neurobiology, University of California, San Diego, La Jolla, United States

16. Department of Physics, University of Oslo, Oslo, Norway

Abstract

Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for (1) the basic understanding of cerebrovascular regulation and (2) interpretation of functional Magnetic Resonance Imaging (fMRI) signals. Using a combination of optogenetic stimulation and 2-photon imaging in mice, we demonstrate that selective activation of cortical excitation and inhibition elicits distinct vascular responses and identify the vasoconstrictive mechanism as Neuropeptide Y (NPY) acting on Y1 receptors. The latter implies that task-related negative Blood Oxygenation Level Dependent (BOLD) fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons. Further, the NPY-Y1 pathway may offer a potential therapeutic target in cerebrovascular disease.

Funder

European Regional Development Fund

International Headache Society

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

John Carroll University, Department of Physics

Deutsche Forschungsgemeinschaft

Natural Sciences and Engineering Research Council of Canada

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

National Institutes of Health

Norges Forskningsråd

Publisher

eLife Sciences Publications, Ltd