Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

Author:

Gallardo Christian M1,Darvas Martin2,Oviatt Mia1,Chang Chris H3,Michalik Mateusz4,Huddy Timothy F5,Meyer Emily E3,Shuster Scott A1,Aguayo Antonio5,Hill Elizabeth M5,Kiani Karun3,Ikpeazu Jonathan1,Martinez Johan S1,Purpura Mari3,Smit Andrea N4,Patton Danica F4,Mistlberger Ralph E4,Palmiter Richard D6,Steele Andrew D15

Affiliation:

1. Division of Biology, California Institute of Technology, Pasadena, United States

2. Department of Pathology, University of Washington, Seattle, United States

3. W M Keck Science Department, Claremont McKenna, Pitzer and Scripps Colleges, Claremont, United States

4. Department of Psychology, Simon Fraser University, Burnaby, Canada

5. Biological Sciences Department, California State Polytechnic University Pomona, Pomona, United States

6. Department of Biochemistry, Howard Hughes Medical Institute, University of Washington, Seattle, United States

Abstract

Daily rhythms of food anticipatory activity (FAA) are regulated independently of the suprachiasmatic nucleus, which mediates entrainment of rhythms to light, but the neural circuits that establish FAA remain elusive. In this study, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly reduced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA. To determine where dopamine exerts its effect, we limited expression of dopamine signaling to the dorsal striatum of dopamine-deficient mice; these mice developed FAA. Within the dorsal striatum, the daily rhythm of clock gene period2 expression was markedly suppressed in D1R KO mice. Pharmacological activation of D1R at the same time daily was sufficient to establish anticipatory activity in wild-type mice. These results demonstrate that dopamine signaling to D1R-expressing neurons in the dorsal striatum plays an important role in manifestation of FAA, possibly by synchronizing circadian oscillators that modulate motivational processes and behavioral output.

Funder

Broad Fellows Program in Brain Circuitry

Ellison Medical Foundation

Howard Hughes Medical Institute

Klarman Family Foundation

Natural Sciences and Engineering Research Council of Canada

National Institutes of Health

Science Educational Enhancement Services Cal Poly Pomona

Claremont McKenna Interdisciplinary Science Scholarship

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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