The role of expectations, control and reward in the development of pain persistence based on a unified model

Author:

Büchel Christian1ORCID

Affiliation:

1. Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf

Abstract

Chronic, or persistent pain affects more than 10% of adults in the general population. This makes it one of the major physical and mental health care problems. Although pain is an important acute warning signal that allows the organism to take action before tissue damage occurs, it can become persistent and its role as a warning signal thereby inadequate. Although per definition, pain can only be labeled as persistent after 3 months, the trajectory from acute to persistent pain is likely to be determined very early and might even start at the time of injury. The biopsychosocial model has revolutionized our understanding of chronic pain and paved the way for psychological treatments for persistent pain, which routinely outperform other forms of treatment. This suggests that psychological processes could also be important in shaping the very early trajectory from acute to persistent pain and that targeting these processes could prevent the development of persistent pain. In this review, we develop an integrative model and suggest novel interventions during early pain trajectories, based on predictions from this model.

Funder

European Research Council

Deutsche Forschungsgemeinschaft

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Cited by 4 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Alcohol use and the pain system;Advances in Drug and Alcohol Research;2024-01-24

2. Orofacial Pain and Dentistry Management: Guidelines for a More Comprehensive Evidence-Based Approach;Diagnostics;2023-09-04

3. Perspectives on emotional memory images and the persistence of pain;Frontiers in Pain Research;2023-07-26

4. Pain;Evolution, Medicine, and Public Health;2023-01-01

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