Rate and oscillatory switching dynamics of a multilayer visual microcircuit model

Author:

Hahn Gerald1ORCID,Kumar Arvind2ORCID,Schmidt Helmut3ORCID,Knösche Thomas R34ORCID,Deco Gustavo1567

Affiliation:

1. Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra

2. Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology

3. Brain Networks Group, Max Planck Institute for Human Cognitive and Brain Sciences

4. Institute of Biomedical Engineering and Informatics, Department of Computer Science and Automation, Technische Universität Ilmenau

5. Institució Catalana de la Recerca i Estudis Avançats

6. Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences

7. School of Psychological Sciences, Turner Institute for Brain and Mental Health, Monash University

Abstract

The neocortex is organized around layered microcircuits consisting of a variety of excitatory and inhibitory neuronal types which perform rate- and oscillation-based computations. Using modeling, we show that both superficial and deep layers of the primary mouse visual cortex implement two ultrasensitive and bistable switches built on mutual inhibitory connectivity motives between somatostatin, parvalbumin, and vasoactive intestinal polypeptide cells. The switches toggle pyramidal neurons between high and low firing rate states that are synchronized across layers through translaminar connectivity. Moreover, inhibited and disinhibited states are characterized by low- and high-frequency oscillations, respectively, with layer-specific differences in frequency and power which show asymmetric changes during state transitions. These findings are consistent with a number of experimental observations and embed firing rate together with oscillatory changes within a switch interpretation of the microcircuit.

Funder

German Research Council

Spanish Research Project COBRAS

Catalan AGAUR program

Horizon 2020 - Research and Innovation Framework Programme

Swedish Research Council

Max Planck Institute for Human Cognitive and Brain Sciences

Spanish Ministry of Science, Innovation and Universities

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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