Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer-Reference-Cited by-同舟云学术

Super-enhancer-driven ZFP36L1 promotes PD-L1 expression in infiltrative gastric cancer

Published:2024-08-08 Issue: Volume: Page:
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Author:

Wei Xujin¹²³^ORCID,Liu Jie¹,Cheng Jia²³,Cai Wangyu²³,Xie Wen²³,Wang Kang²³,Lin Lingyun²³,Hou Jingjing²³,Zhuo Huiqin²³,Cai Jianchun¹²³^ORCID

Affiliation:

1. The Graduate School of Fujian Medical University

2. Department of Gastrointestinal Surgery, Zhongshan Hospital of Xiamen University, Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University

3. Xiamen Municipal Key Laboratory of Gastrointestinal Oncology

Abstract

Gastric cancer (GC) is a major cause of cancer-related mortality worldwide. Despite the widespread recognition of tumor immunotherapy in treating unresectable GC, challenges, including ineffective immunotherapy and drug resistance, persist. Therefore, understanding the regulatory mechanisms of PD-L1, particularly in the context of super-enhancers (SEs) and zinc finger protein 36 ring finger protein-like 1 (ZFP36L1) RNA-binding protein, is crucial.

Publisher

eLife Sciences Publications, Ltd

Link

https://elifesciences.org/reviewed-preprints/96445v1/pdf

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