Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors

Author:

Beekhof Gerrit Cornelis1ORCID,Osório Catarina1ORCID,White Joshua J1ORCID,van Zoomeren Scott1,van der Stok Hannah1ORCID,Xiong Bilian1,Nettersheim Ingo HMS1ORCID,Mak Willem Ashwin1,Runge Marit1,Fiocchi Francesca Romana1,Boele Henk-Jan12,Hoebeek Freek E13,Schonewille Martijn1ORCID

Affiliation:

1. Department of Neuroscience, Erasmus MC, Rotterdam, Netherlands

2. Princeton Neuroscience Institute, Princeton, United States

3. Department for Developmental Origins of Disease, University Medical Center Utrecht Brain Center and Wilhelmina Children’s Hospital, Utrecht, Netherlands

Abstract

Distinct populations of Purkinje cells (PCs) with unique molecular and connectivity features are at the core of the modular organization of the cerebellum. Previously, we showed that firing activity of PCs differs between ZebrinII-positive and ZebrinII-negative cerebellar modules (Zhou et al., 2014; Wu et al., 2019). Here, we investigate the timing and extent of PC differentiation during development in mice. We found that several features of PCs, including activity levels, dendritic arborization, axonal shape and climbing fiber input, develop differentially between nodular and anterior PC populations. Although all PCs show a particularly rapid development in the second postnatal week, anterior PCs typically have a prolonged physiological and dendritic maturation. In line herewith, younger mice exhibit attenuated anterior-dependent eyeblink conditioning, but faster nodular-dependent compensatory eye movement adaptation. Our results indicate that specific cerebellar regions have unique developmental timelines which match with their related, specific forms of cerebellum-dependent behaviors.

Funder

H2020 European Research Council

ZonMw

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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