Spatial modulation of visual responses arises in cortex with active navigation

Author:

Diamanti E Mika12ORCID,Reddy Charu Bai1ORCID,Schröder Sylvia1ORCID,Muzzu Tomaso3ORCID,Harris Kenneth D4ORCID,Saleem Aman B3ORCID,Carandini Matteo1ORCID

Affiliation:

1. UCL Institute of Ophthalmology, University College London, London, United Kingdom

2. CoMPLEX, Department of Computer Science, University College London, London, United Kingdom

3. UCL Institute of Behavioural Neuroscience, University College London, London, United Kingdom

4. UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

Abstract

During navigation, the visual responses of neurons in mouse primary visual cortex (V1) are modulated by the animal’s spatial position. Here we show that this spatial modulation is similarly present across multiple higher visual areas but negligible in the main thalamic pathway into V1. Similar to hippocampus, spatial modulation in visual cortex strengthens with experience and with active behavior. Active navigation in a familiar environment, therefore, enhances the spatial modulation of visual signals starting in the cortex.

Funder

EPSRC

Wellcome Trust/ Royal Society

Wellcome Trust

Human Frontier Science Program

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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