Neuronal connectome of a sensory-motor circuit for visual navigation

Author:

Randel Nadine1,Asadulina Albina1,Bezares-Calderón Luis A1,Verasztó Csaba1,Williams Elizabeth A1,Conzelmann Markus1,Shahidi Réza1,Jékely Gáspár1

Affiliation:

1. Max Planck Institute for Developmental Biology, Tübingen, Germany

Abstract

Animals use spatial differences in environmental light levels for visual navigation; however, how light inputs are translated into coordinated motor outputs remains poorly understood. Here we reconstruct the neuronal connectome of a four-eye visual circuit in the larva of the annelid Platynereis using serial-section transmission electron microscopy. In this 71-neuron circuit, photoreceptors connect via three layers of interneurons to motorneurons, which innervate trunk muscles. By combining eye ablations with behavioral experiments, we show that the circuit compares light on either side of the body and stimulates body bending upon left-right light imbalance during visual phototaxis. We also identified an interneuron motif that enhances sensitivity to different light intensity contrasts. The Platynereis eye circuit has the hallmarks of a visual system, including spatial light detection and contrast modulation, illustrating how image-forming eyes may have evolved via intermediate stages contrasting only a light and a dark field during a simple visual task.

Funder

European Commission (EC)

Max Planck Society

Max-Planck-Gesellschaft

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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