A broad mutational target explains a fast rate of phenotypic evolution

Author:

Besnard Fabrice12ORCID,Picao-Osorio Joao1,Dubois Clément1,Félix Marie-Anne1

Affiliation:

1. Institut de Biologie de l'École Normale Supérieure, CNRS, Inserm, Paris, France

2. Laboratoire Reproduction et Développement des Plantes, Univ Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRAE, Inria, Lyon, France

Abstract

The rapid evolution of a trait in a clade of organisms can be explained by the sustained action of natural selection or by a high mutational variance, that is the propensity to change under spontaneous mutation. The causes for a high mutational variance are still elusive. In some cases, fast evolution depends on the high mutation rate of one or few loci with short tandem repeats. Here, we report on the fastest evolving cell fate among vulva precursor cells inCaenorhabditisnematodes, that of P3.p. We identify and validate causal mutations underlying P3.p's high mutational variance. We find that these positions do not present any characteristics of a high mutation rate, are scattered across the genome and the corresponding genes belong to distinct biological pathways. Our data indicate that a broad mutational target size is the cause of the high mutational variance and of the corresponding fast phenotypic evolutionary rate.

Funder

Agence Nationale de la Recherche

H2020 Marie Skłodowska-Curie Actions

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference101 articles.

1. A developmental analysis of an evolutionary trend: digital reduction in amphibians;Alberch;Evolution,1985

2. Andrews S. 2017. FastQC: A Quality Control Tool for Hgh Throughput Sequence Data. http://www.bioinformatics.babraham.ac.uk/projects/fastqc.

3. Using transcriptomes as mutant phenotypes reveals functional regions of a mediator subunit in Caenorhabditis elegans;Angeles-Albores;Genetics,2018

4. Efficient marker-free recovery of custom genetic modifications with CRISPR/Cas9 in Caenorhabditis elegans;Arribere;Genetics,2014

5. Biased Embryos and Evolution

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