Molecular insights into the origin of the Hox-TALE patterning system

Author:

Hudry Bruno1,Thomas-Chollier Morgane2,Volovik Yael3,Duffraisse Marilyne4,Dard Amélie4,Frank Dale3,Technau Ulrich5,Merabet Samir4

Affiliation:

1. MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom

2. Unité Mixte de Recherche (UMR) 8197, INSERM U1024, Institut de Biologie de l’ENS (IBENS), Ecole Normale Supérieure (ENS), Centre National de Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Scientifique (INSERM), Paris, France

3. Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

4. Unité Mixte de Recherche (UMR) 5242, Institut de Génomique Fonctionnelle de Lyon (IGFL), Ecole Normale Supérieure (ENS) de Lyon, Centre National de Recherche Scientifique (CNRS), Lyon, France

5. Department für Molekulare Evolution und Entwicklung, University of Vienna, Vienna, Austria

Abstract

Despite tremendous body form diversity in nature, bilaterian animals share common sets of developmental genes that display conserved expression patterns in the embryo. Among them are the Hox genes, which define different identities along the anterior–posterior axis. Hox proteins exert their function by interaction with TALE transcription factors. Hox and TALE members are also present in some but not all non-bilaterian phyla, raising the question of how Hox–TALE interactions evolved to provide positional information. By using proteins from unicellular and multicellular lineages, we showed that these networks emerged from an ancestral generic motif present in Hox and other related protein families. Interestingly, Hox-TALE networks experienced additional and extensive molecular innovations that were likely crucial for differentiating Hox functions along body plans. Together our results highlight how homeobox gene families evolved during eukaryote evolution to eventually constitute a major patterning system in Eumetazoans.

Funder

Association pour la Recherche contre le Cancer

Fondation pour la Recheche Medicale

EMBO short term fellow

Fondation ARC pour la Recherche sur le Cancer

Fondation pour la Recherche Médicale

EMBO

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

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