Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit-Reference-Cited by-同舟云学术

Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

Published:2020-08-24 Issue: Volume:9 Page:
ISSN:2050-084X
Container-title:eLife
language:en
Short-container-title:

Author:

Díaz-Alonso Javier¹^ORCID,Morishita Wade²,Incontro Salvatore¹,Simms Jeffrey³,Holtzman Julia³,Gill Michael³,Mucke Lennart³⁴,Malenka Robert C²,Nicoll Roger A¹^ORCID

Affiliation:

1. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States

2. Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, United States

3. Gladstone Institute of Neurological Disease, San Francisco, United States

4. Department of Neurology, University of California, San Francisco, San Francisco, United States

Abstract

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.

Funder

National Institute of Mental Health

Publisher

eLife Sciences Publications, Ltd

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://cdn.elifesciences.org/articles/58042/elife-58042-v2.pdf

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